在当时，1,1,1,2-四氟乙烷的生产设施均属帝国化学工业公司（ICI）所有。2001年1月，所有权转移到英力士氟化学手里，最近，即2010年4月，美希氟化学取得了这些工厂的所有权。虽然生产设施和所有权发生了变化，但产品的性能一直没有改变上海翻译公司。

At the time Mexichem Fluor’s manufacturing facilities for 1,1,1,2-tetrafluoroethane were owned and operated by Imperial Chemical Industries PLC (ICI).  Since then the ownership has passed to the INEOS Fluor (January 2001) and more recently to Mexichem Fluor (April 2010).  The manufacturing facilities and heritage of this product have remained unchanged despite the changes of ownership.

工艺的第一个关键步骤，是根据杂质的毒理学知识，确定1,1,1,2-四氟乙烷中的杂质的允许含量。因此，来自格兰索（现称葛兰素史克）和ICI（现属美希氟化学）的毒理学专家、质量保证人员和生产人员组成了一个工作组，确定1,1,1,2-四氟乙烷的毒性等级以便完成毒性评估。先确定出毒性级1,1,1,2-四氟乙烷的允许杂质含量，然后以此编写出口服药用产品的技术规范英语翻译。

One of the critical first steps was to establish acceptable levels (based on toxicolgical knowledge of these impurities) for these impurities in the 1,1,1,2-tetrafluoroethane.  To this end an expert working group was established between Glaxo (now GlaxoSmithKline) and ICI (now Mexichem Fluor) comprising toxicologists, quality assurance personnel and manufacturing personnel.   A toxicological grade of 1,1,1,2-tetrafluoroethane was developed for toxicological evaluation.  From the toxicological evaluation acceptable levels of impurities in the 1,1,1,2-tetrafluoroethane would be determined, and a specification for the pharmaceutical (inhalation) grade of product derived.